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Long-Term Memory: What is that Elephantine Memory?

Elephantine memory So far, we have looked at sensory memory and short-term memory both of which last for under a minute. So how does one go about acquiring an elephantine memory? What are the secrets of long-term memory? Long-term memory involves actual physical changes made to the brain and is virtually limitless. In our computer, […]

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Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors.

Authors: Stein LR, Zorumski CF, Imai SI, Izumi Y Abstract Nicotinamide adenine dinucleotide (NAD(+)) is an essential coenzyme/cosubstrate for many biological processes in cellular metabolism. The rate-limiting step in the major pathway of mammalian NAD(+) biosynthesis is mediated by nicotinamide phosphoribosyltransferase (Nampt). Previously, we showed that mice lacking Nampt in forebrain excitatory neurons (CamKIIαNampt(-/-) mice) […]

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