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Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors.

Authors: Stein LR, Zorumski CF, Imai SI, Izumi Y Abstract Nicotinamide adenine dinucleotide (NAD(+)) is an essential coenzyme/cosubstrate for many biological processes in cellular metabolism. The rate-limiting step in the major pathway of mammalian NAD(+) biosynthesis is mediated by nicotinamide phosphoribosyltransferase (Nampt). Previously, we showed that mice lacking Nampt in forebrain excitatory neurons (CamKIIαNampt(-/-) mice) […]

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