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Connection Between Brain, Depression and Effectiveness of Chemotherapy

Chemotherapy is a type of therapy that uses various, rather aggressive, medicines to eliminate cancer cells from the body or slow down the growth of tumors. Cancer cells are different from normal cells as they reproduce a lot faster. Chemotherapy specifically targets the fast dividing cells and thus affects cancer cells the most. However, chemotherapy […]

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New Target in Brain for Treating Depression — The BMP Pathway

A significant number of patients do not respond to antidepressant drugs, and some even feel worse, a somber fact that emphasizes the urgent need to find other treatment options. In a new study on mice, scientists at Northwestern Medicine have discovered a pathway in the brain that may be a promising new drug target for […]

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Sad and in Pain – The Link Between Migraine and Depression

Migraine is one of the most common painful disorders afflicting one in every eight people. It is characterized by throbbing and relatively unpredictable episodes of head pain that may last up to three days. Various studies have shown that patients with migraine have a higher frequency of depression and anxiety: a finding that will be […]

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Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors.

Authors: Stein LR, Zorumski CF, Imai SI, Izumi Y Abstract Nicotinamide adenine dinucleotide (NAD(+)) is an essential coenzyme/cosubstrate for many biological processes in cellular metabolism. The rate-limiting step in the major pathway of mammalian NAD(+) biosynthesis is mediated by nicotinamide phosphoribosyltransferase (Nampt). Previously, we showed that mice lacking Nampt in forebrain excitatory neurons (CamKIIαNampt(-/-) mice) […]

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Veterans and Clinical Depression

It is commonly known that prolonged exposure to combat can serve as a serious trigger for veterans to develop any sort of mental illness. Two types of mental illness, Post-Traumatic Stress Disorder and depression, are some of the most common, and many of the symptoms overlap, causing frequent …

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